When Jesus preached and healed people in His hometown most of the people rejected Him. This must have been greatly discouraging.

Mark 6:

2 The next Sabbath he began teaching in the synagogue, and many who heard him were amazed. They asked, “Where did he get all this wisdom and the power to perform such miracles?” 3 Then they scoffed, “He’s just a carpenter, the son of Mary and the brother of James, Joseph, Judas, and Simon. And his sisters live right here among us.” They were deeply offended and refused to believe in him.

4 Then Jesus told them, “A prophet is honored everywhere except in his own hometown and among his relatives and his own family.” 5 And because of their unbelief, he couldn’t do any miracles among them except to place his hands on a few sick people and heal them. 6 And he was amazed at their unbelief. Then Jesus went from village to village, teaching the people.